منابع مشابه
Introduction Plasma Hyaluronidase (Hyal-1) Genomic Organization of the Hyaluronidase Sequences Hyaluronidase Genes on Chromosome 3p21.3 Hyaluronidase Genes on Chromosome 7q31.3 Implications for Clinical Medicine Hyaluronidases in Cancer
he has focused on the biology of hyaluronan and the hyaluronidases. He is also a board-certified Anatomic Pathologist and participates in the teaching and diagnostic services of the Department of Pathology. He is currently a visiting scientist in the laboratory of Dr. Robert Stern in San Francisco. In addition to hyaluronan and hyaluronidase, his interests include the process of aging and the b...
متن کاملEmerging roles for hyaluronidase in cancer metastasis and therapy.
Hyaluronidases are a family of five human enzymes that have been differentially implicated in the progression of many solid tumor types, both clinically and in functional studies. Advances in the past 5 years have clarified many apparent contradictions: (1) by demonstrating that specific hyaluronidases have alternative substrates to hyaluronan (HA) or do not exhibit any enzymatic activity, (2) ...
متن کاملHYAL1 hyaluronidase in prostate cancer: a tumor promoter and suppressor.
Hyaluronidases degrade hyaluronic acid, which promotes metastasis. HYAL1 type hyaluronidase is an independent prognostic indicator of prostate cancer progression and a biomarker for bladder cancer. However, it is controversial whether hyaluronidase (e.g., HYAL1) functions as a tumor promoter or as a suppressor. We stably transfected prostate cancer cells, DU145 and PC-3 ML, with HYAL1-sense (HY...
متن کاملPromoter and Suppressor HYAL1 Hyaluronidase in Prostate Cancer: A Tumor
Hyaluronidases degrade hyaluronic acid, which promotes metastasis. HYAL1 type hyaluronidase is an independent prognostic indicator of prostate cancer progression and a biomarker for bladder cancer. However, it is controversial whether hyaluronidase (e.g., HYAL1) functions as a tumor promoter or as a suppressor. We stably transfected prostate cancer cells, DU145 and PC-3 ML, with HYAL1-sense (HY...
متن کاملHyaluronidase and peribulbar block.
We have assessed the effect of two concentrations of hyaluronidase on the quality of peribulbar block, using a low volume, single injection technique. We studied 200 patients undergoing elective intraocular surgery, allocated randomly to one of three groups. Group 1 (n = 50) received peribulbar block with 5 ml of a 1:1 mixture of 0.5% plain bupivacaine and 2% plain lignocaine. Group 2 (n = 75) ...
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ژورنال
عنوان ژورنال: Journal of Clinical Pathology
سال: 1967
ISSN: 0021-9746
DOI: 10.1136/jcp.20.3.306-c